TABLE OF CONTENTS
Title page
Certification = = = = = = = ii
Dedication = = = = = = = iii
Acknowledgment = = = = = = = iv
Abstract = = = = = = = = V
Table of content = = = = = = = vi
CHAPTER ONE
1.0 Introduction = = = = = = 1
1.2 Factors important in determining the
rate at which a drug is absorbed from
its site of administration are = = = 5
1.3 Effect of microorganisms on drugs = = 6
1.4 Systemic availability of drug = = = 7
1.5 Raw materials = = = = = = 12
1.6 Water supply = = = = = = = 13
1.7 Air = = = = = = = = 13
1.8 Equipment = = = = = = = 14
1.9 Personnel = = = = = = = 15
1.10 Containers/packaging materials = = 16
CHAPTER TWO
2.0 Literature review = = = = = 17
CHAPTER THREE
3.0 Materials and methods = = = = 22
3.1 Sterilization of materials and
aseptic techniques = = = = = 23
3.2 Pharmaceutical industry visited = = 23
3.3 Collection of samples = = = = 23
3.4 Preparation of media = = = = = 24
3.5 Analysis of the samples = = = = 24
3.6 Sub culturing of samples = = = = 25
3.7 Isolation of bacterial on selective media = 26
3.8 Identification of isolates = = = = = 26
3.9 Method of preparation of media = = 27
3.10 Gram’s-staining = = = = = 28
3.11 Catalase test = = = = = = 29
3.12 Indole test = = = = = = 29
3.13 Motility test = = = = = = = 30
13.14 Methyl red test = = = = 30
3.15 Voges proskauer test = = = 31
3.16 Sugar fermentation test = = = 32
3.17 Triple sugar iron agar (TSI) 32
3.18 Colonial and cellular characteristics
of organisms isolated in drul4g sample on
different media = = = = = = 33
CHAPTER FOUR
4.0 Discussion and Conclusion = = 36
Conclusion = = = = = = 41
Recommendations = = = = = 43
References = = = = = = 44
Appendix 1 = = = = = = 47
Appendix 2 = = = = = = 52